Endocrine Abstracts

Introduction: To evaluate the impact of a long-term telemonitoring programme for patients with type 2 diabetes mellitus (DMT2) on glycaemic control and lipid disorders.Methods/design: In the Greek pilot of a prospective, randomised, single-blinded, multicentre study 154 patients with DMT2, HbA1c >53 mmol/mol (7.0% according to NGSP) and capable of using the telemonitoring device, were studied after randomly assigned in the telemonitoring (IG) (n<...

Introduction: In 30–50% of cases central diabetes insipidus (CDI) is idiopathic. Other causes include tumours, pituitary surgery, cranial trauma or infiltrative diseases. Long-term medical follow-up is crucial given that idiopathic CDI can be the earliest sign of an evolving process (inflammatory or tumoural).Case report: We report the case of a 23-year-old woman who presented with isolated polydipsia and polyuria. The diagnosis of isolated CDI was ...

Introduction: Ultrasound-guided fine needle aspiration biopsy (US-FNAB) enables selective sampling of thyroid follicular cells while minimizing potential complications. Inadequate specimen sampling can lead to FNAB repeat. Our aim was to evaluate the morphological and cytological characteristics of thyroid nodules with US and rapid on-site evaluation of adequacy (ROSE).Methods: Two independent endocrinologists evaluated nodule characteristics of 171 US-F...

Background: Previous research has demonstrated positive effects of Orthodox fasting (OF) and time restricted eating (TRE) on body weight (BW). However, little is known about the late, metabolic effects of the two diets.Methods: 29 overweight adults followed a hypocaloric diet based on OF. A hypocaloric, TRE plan (eating between 08:00 to 16:00 h) was followed by 16 BW-matched participants. Anthropometric, glycemic and inflammation markers and serum lipids...

Background: Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disorder characterized by the presence of endocrine and nonendocrine tumors. Until recently, more than 450 different germline mutations have been reported in MEN1 patients involving frameshift deletions, insertions, as well as nonsense mutations.Aim: To report a novel mutation in MEN1 gene in a young female with persisting primary hyperparathyroidism.<p class="ab...

Objective: Androgen may be detrimental in the development of cardiovascular disease in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and thus the tissue androgen availability and early markers of atherosclerosis in apparently healthy women.Design and methods: In this prospective clinical study, 153 con...

Hypothalamic hormonal deficiency and anterior pituitary hormonal deficiency is a rare occurrence in patients presenting with HIV infection. We describe a patient with HIV infection who presented with secondary amenorrhea as the initial manifestation.Case report: A 34-year-old woman with previously regular menses presented with secondary amenorrhea by 9 months. The patient had mild gait instability for 7 months; anorexia and weight loss (10 kg) for the la...

Introduction: Bariatric surgery is a revolutionary method for the treatment of morbid obesity. It is effective as far as weight control is concerned, for the prevention and treatment of diabetes mellitus and the metabolic syndrome. However, bariatric surgery may be accompanied by adverse effects if postoperatively dietary instructions are not adhered to.Aim: The aim was to present a case of a patient who underwent sleeve gastrectomy for the treatment of ...

Introduction: Evidence supports the prognostic value of preablative stimulated thyroglobulin (ps-Tg) for recurrent and persistent disease in patients with differentiated thyroid cancer (DTC). The correlation of ps-Tg with therapeutic response however has been less studied.Objective: To study the correlation of ps-Tg and the trend of serial preablative thyroglobulin measurements(DTg) with the response to treatment restaging system proposed in 2015 America...

IntroductionAlemtuzumab is an anti-CD52 antibody, leading to lysis and transient depletion of T and B lymphocytes. Its therapeutic effect is mediated by the alteration in immune repertoire that accompanies subsequent lymphocyte reconstitution. It is mainly used for the treatment of relapsing–remitting multiple sclerosis (RRMS). Common side effects are autoimmune diseases, including thyroid disease (>40%), immune thrombocytopenia (IT...